Project
Targeting alternative splicing for cancer therapy using South African medicinal plants and phytocompounds
Cancer is one of the leading causes of death worldwide including South Africa.
Project
Impaired migration and lung invasion of human melanoma by a novel small molecule targeting the transmembrane domain of death receptor p75NTR
Lopes-Rodrigues, V., Nyantakyi, S. A., Lun, X., Han, X., Zhang, J., Ramanujan, A., Salim, S., Saleeb, M., Babes, L., Chou, A. Z., Du, L., Do...
Project
Generation of a Chronic Myeloid Leukemia single-cell genomic atlas
Chronic Myeloid Leukemia (CML) is an aggressive type of blood cancer that requires life-long therapy.
Project
Identification of novel biomarkers for gynecological cancer – when is screening becoming a reality?
Over 1.3 million women are each year diagnosed with one of three major gynecologic cancers, ovarian cancer, endometrial cancer or cervical cancer.
Publication
Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer
Gyllensten, Ulf, Julia Hedlund-Lindberg, Johanna Svensson, Johanna Manninen, Torbjörn Öst, Jon Ramsell, Matilda Åslin, Emma Ivansson, Marta ...
Project
Review on the use of BTK inhibitors
The beauty of BTK inhibitors is that they impair tumor development by blocking normal, unmutated BTK, causing many lymphoid tumors to be sensitive, as we have reviewed.
Publication
A concise review on the frequency, major risk factors and surveillance of hepatocellular carcinoma (hcc) in β-thalassemias: past, present and future perspectives
De Sanctis, Vincenzo, Ashraf T. Soliman, Shahina Daar, Niveen Alansary, Antonis Kattamis, Myrto Skafida, Maria Concetta Galati, Soteroula Ch...
Publication
Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approach
Guebel, Daniel V.; Schmitz, Ulf; Wolkenhauer, Olaf; et al. 2012. Analysis of cell adhesion during early stages of colon cancer based on an e...
Publication
The Role of microRNAs in the Resistance to Colorectal Cancer Treatments
Amirkhah, Raheleh, Ali Farazmand, Muhammad Irfan-Maqsood, Olaf Wolkenhauer, and Ulf Schmitz. 2015. The Role of microRNAs in the Resistance t...
Publication
Personalized Cancer Immunotherapy Using Systems Medicine Approaches
Gupta, Shailendra K, Tanushree Jaitly, Ulf Schmitz, Gerold Schuler, Olaf Wolkenhauer, and Julio Vera. 2016. Personalized Cancer Immunotherap...
Publication
RNA Systems Biology for Cancer: From Diagnosis to Therapy
Amirkhah, Raheleh, Ali Farazmand, Olaf Wolkenhauer, and Ulf Schmitz. 2016. RNA Systems Biology for Cancer: From Diagnosis to Therapy. Pp. 30...
Project
Cancer treatment by manipulation of mitochondria
Cancer is the second leading cause of death globally, and to reduce this societal and economic burden new treatment options will be needed.
Project
Systematic generation of an update of the ongoing studies on the new BTK inhibitors
BTK is a cytoplasmic protein-tyrosine kinase, whose corresponding gene was isolated in the early 1990s.