Project
Understanding Alzheimer’s Disease: Basic mechanisms and clinical developments
The abnormal processing of amyloid precursor protein (APP), aggregation of Aβ, Tau hyper phosphorylation and propagation of these abnormally folded proteins have been collectively recognized as hallmarks of the initial, biochemical phase of Alzheimer’s Disease (AD) [De Strooper 2016].
Project
Making Mouse Models That Better Reflect Human Metabolic and Neurological Diseases
In addition to their well known functions in the controlling infections, immune cells and inflammatory reactions play crucial roles in metabolic and neurodegenerative diseases, such as obesity and Alzheimer’s disease.
Publication
Inactive variants of death receptor p75ᴺᵀᴿ reduce Alzheimer’s neuropathology by interfering with APP internalization
Yi, Chenju, Ket Yin Goh, Lik-Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar and Carlos F. Ibáñez. 2020. Inactive variants...