Project
Understanding Emergence
Emergent behaviour seems to be characteristic of the `complex systems that currently feature in Mathematics, Computer Science, the Physical Sciences and Philosophy.
Project
HIV Strain Dynamics
A growing concern in HIV research is the emergence of drug resistant strains of the virus.
Project
Merging the layers of life
Developing a (mathematical) model suitable for the integration of the different levels of biological research (sub-molecular, molecular, organisms, populations) in one framework.
Publication
Thresholds in transient dynamics of signal transduction pathways
K Rateitschak and O Wolkenhauer. 2009. Thresholds in transient dynamics of signal transduction pathways. IET Systems Biology
Publication
A stem cell niche dominance theorem
Olaf Wolkenhauer, Darryl K Shibata, Mihajlo D Mesarovi? 2011. A stem cell niche dominance theorem. BMC Systems Biology, 5 (4), 16 pp. http:/...
Publication
Analysis of cell adhesion during early stages of colon cancer based on an extended multi-valued logic approach
Guebel, Daniel V.; Schmitz, Ulf; Wolkenhauer, Olaf; et al. 2012. Analysis of cell adhesion during early stages of colon cancer based on an e...
Publication
The role of theorem proving in systems biology
Wolkenhauer, Olaf; Shibata, Darryl; Mesarovic, Mihajlo D. 2012. The role of theorem proving in systems biology. JOURNAL OF THEORETICAL BIOLO...
Publication
Why model?
Olaf Wolkenhauer. 2014. Why model? Froniers in Physiology, 5 (21), 1-14. doi:10.3389/fphys.2014.00021
Publication
Enabling multiscale modeling in systems medicine
Olaf Wolkenhauer, Charles Auffray, Olivier Brass, et al. 2014. Enabling multiscale modeling in systems medicine. Genome Medicine, 6 (3) Arti...
Publication
Hybrid modeling of the crosstalk between signaling and transcriptional networks using ordinary differential equations and multi-valued logic
Faiz M. Khan, Ulf Schmitz, Svetoslav Nikolov, David Putzer, Brigitte M. Puetzer, Olaf Wolkenhauer and Julio Vera. 2014. Hybrid modeling of t...
Publication
The balance between cell cycle arrest and cell proliferation: control by the extracellular matrix and by contact inhibition
Claude Gerard and Albert Goldbeter. 2014. The balance between cell cycle arrest and cell proliferation: control by the extracellular matrix ...
Publication
Pushing Limits by Embracing Complexity
Wolkenhauer, Olaf. 2014. Pushing Limits by Embracing Complexity. IET Systems Biology 8 (6): 244–50. doi:10.1049/iet-syb.2014.0031.
Publication
Anti-Inflammatory Effects of Reactive Oxygen Species – a Multi-Valued Logical Model Validated by Formal Concept Analysis
Wollbold, Johannes, Robert Jaster, Sarah Müller, Katja Rateitschak, and Olaf Wolkenhauer. 2014. Anti-Inflammatory Effects of Reactive Oxygen...
Publication
Coenzyme A-Transferase-Independent Butyrate Re-Assimilation in Clostridium Acetobutylicum—evidence from a Mathematical Model
Millat, Thomas, Christine Voigt, Holger Janssen, Clare M. Cooksley, Klaus Winzer, Nigel P. Minton, Hubert Bahl, Ralf-Jörg Fischer, and Olaf ...
Publication
An Explicit Numerical Scheme to Efficiently Simulate Molecular Diffusion in Environments with Dynamically Changing Barriers
Kossow, Christina, Stefan Rybacki, Thomas Millat, Katja Rateitschak, Robert Jaster, Adelinde M. Uhrmacher, and Olaf Wolkenhauer. 2015. An Ex...
Publication
Gata6, Nanog and Erk Signaling Control Cell Fate in the Inner Cell Mass through a Tristable Regulatory Network
Bessonnard, S., L. De Mot, D. Gonze, M. Barriol, C. Dennis, A. Goldbeter, G. Dupont, and C. Chazaud. 2014. Gata6, Nanog and Erk Signaling Co...
Publication
Dynamics of the Mammalian Cell Cycle in Physiological and Pathological Conditions
Gérard, Claude and Albert Goldbeter. 2016. Dynamics of the Mammalian Cell Cycle in Physiological and Pathological Conditions. Wiley Interdis...
Publication
Systems Medicine
Schmitz, Ulf and Olaf Wolkenhauer. 2016. Systems Medicine. edited by Ulf Schmitz and Olaf Wolkenhauer. New York, NY: Springer New York. http...
Publication
Thrombosis in Cerebral Aneurysms and the Computational Modeling Thereof: A Review
Ngoepe, Malebogo N., Alejandro F. Frangi, James V. Byrne and Yiannis Ventikos. 2018. Thrombosis in Cerebral Aneurysms and the Computational ...
Project
Complexity and Anticipation
Complexity is possibly the most relevant scientific idea that emerged during the past decades.
Project
Synthesis, Design, and Resource Optimization in Batch Chemical Plants
The project at STIAS will involve writing a research book aimed at closing a glaring scientific gap in the area of batch chemical process.
Project
Revised edition of the book ‘Biochemical Oscillations and Cellular Rhythms’
A second edition of the book (entitled Biochemical Oscillations and Cellular Rhythms.