Project
Human models to understand and treat autoimmune disorders
We will use different approaches to clarify what initiates an autoimmune disease and to devise better treatment.
Project
Macrophages in Human Tissues-Phenotypic Diversity in Health and Disease
Macrophages represent a heterogeneous family of white blood cells which are widely distributed throughout the body.
Project
The Pitfalls of Reductionism in Vaccine Research
Reductionism has been the predominant research strategy of molecular and structural biology in the 20th century.
Project
Making Mouse Models That Better Reflect Human Metabolic and Neurological Diseases
In addition to their well known functions in the controlling infections, immune cells and inflammatory reactions play crucial roles in metabolic and neurodegenerative diseases, such as obesity and Alzheimer’s disease.
Publication
The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii
Jonathan C. Howard, Julia P. Hunna and Tobias Steinfeldt. 2011. The IRG protein-based resistance mechanism in mice and its relation to virul...
Publication
Tissue macrophage heterogeneity: issues and prospects
Siamon Gordon and Annette Plűddemann. 2013. Tissue macrophage heterogeneity: issues and prospects. Seminars in Immunopathology, 35 (5), 533-...
Publication
Basic research in HIV vaccinology is hampered by reductionist thinking (Review)
Marc H V van Regenmortel. 2013. Basic research in HIV vaccinology is hampered by reductionist thinking (Review). Frontiers in immunology, 3,...
Publication
Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition
Marc H V Van Regenmortel. 2014. Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition. Journal of molecular re...
Publication
High-Dose Vitamin D3 Reduces Deficiency Caused by Low UVB Exposure and Limits HIV-1 Replication in Urban Southern Africans
Coussens, Anna K, Celeste E Naude, Rene Goliath, George Chaplin, Robert J Wilkinson, and Nina G Jablonski. 2015. High-Dose Vitamin D3 Reduce...
Project
The Scientific Method in Biology and Biomedicine (2)
Work on the book ‘The Scientific Method in Biology and Biomedicine’ will be continued.