Project
Breaking the ice: how integrating cryogenic Electron Microscopy can overcome historical scientific isolation and enable local pharmaceutical and vaccine Development in South Africa.
With the award of the 2017 Nobel Prize in Chemistry to three pioneers in cryogenic electron microscopy, the world was awakened to the cutting-edge technology of 'cryo-EM'.
Project
Targeting alternative splicing for cancer therapy using South African medicinal plants and phytocompounds
Cancer is one of the leading causes of death worldwide including South Africa.
Project
Alternative targets for Antibiotics, fighting infection with higher specificity
Antibiotic resistant is a global problem that will only increase over time and is further highly relevant for the tuberculosis patients of South Africa.
Publication
Mce3R Stress-Resistance Pathway Is Vulnerable to Small-Molecule Targeting That Improves Tuberculosis Drug Activities
Yang, Xinxin, Tianao Yuan, Rui Ma, Kieran I Chacko, Melissa Smith, Gintaras Deikus, Robert Sebra, Andrew Kasarskis, Harm van Brakel, Scott G...
Publication
Hit Generation in TB Drug Discovery: From Genome to Granuloma
Yuan, Tianao and Nicole S. Sampson. 2018. Hit Generation in TB Drug Discovery: From Genome to Granuloma. Chemical Reviews, 118(4), 1887–1916...