Project
Understanding Alzheimer’s Disease: Basic mechanisms and clinical developments
The abnormal processing of amyloid precursor protein (APP), aggregation of Aβ, Tau hyper phosphorylation and propagation of these abnormally folded proteins have been collectively recognized as hallmarks of the initial, biochemical phase of Alzheimer’s Disease (AD) [De Strooper 2016].
Publication
Inactive variants of death receptor p75ᴺᵀᴿ reduce Alzheimer’s neuropathology by interfering with APP internalization
Yi, Chenju, Ket Yin Goh, Lik-Wei Wong, Ajeena Ramanujan, Kazuhiro Tanaka, Sreedharan Sajikumar and Carlos F. Ibáñez. 2020. Inactive variants...
Publication
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer’s disease
Schmidt, Vanessa; Baum, Katharina; Lao ,Angelyn; Wolkenhauer, Olaf et al. 2012. Quantitative modelling of amyloidogenic processing and its i...
Project
“Dementia: a growing problem in South Africa and the world”
Prosperous people live longer and old age carries a high risk of dementia, a condition that is so far neither preventable nor curable.